The effect of etomidate combined with dexmetomidine on postoperative cognitive and memory function in elderly patients during ureteroscopic holmium laser lithotripsy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800015421

Enrollment

Unknown

Registered

2018-03-29

Start date

2018-04-05

Completion date

Unknown

Last updated

2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive function and memory function

Interventions

Group 1:anesthesia was maintained with Propofol and remifentanil

Group 2:Intraoperative anesthesia was maintained with Etomidate and rifentanil

Group 3:Intraoperative anesthesia was maintained with Etomidate compound dexmedetomidine - rifentanil anesthesia

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients selected to perform the ureteral holmium laser lithotripsy aged 60 to 75 years old, with no serious liver, kidney and cardiovascular disease before surgery, BMI 20-24.

Exclusion criteria

Exclusion criteria: State of consciousness, cognitive function and mental behavior were abnormal, history of drug or alcohol addiction, sedative drugs was used recently, allergic to propofol, etomidate, remifentanil or dexmetomidine.

Design outcomes

Primary

Measure	Time frame
Digital memory;mini-mental state examination;Zung self rating Depression Scale score;State-Trait Anxiety Inventory;	—

Secondary

Measure	Time frame
Plasma cortisol;ACTH;S-100ß protein;neuron-specific enolase;	—

Countries

China

Contacts

Public ContactWang Fangjun

Affiliated Hospital of North Sichuan Medical College

wfjlxy006@126.com+86 13458253172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 9, 2026