Parkinson's disease
Conditions
Interventions
de novo PD patients:levodopa 4 weeks
de novo PD patients:pramipexole 4 weeks
de novo PD patients:selegiline 4 weeks
Sponsors
Institute of Psychology, Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) idiopathic PD; 2) aged 50-80 years; 3) education >=9 years; 4) Hoehn-Yahr 1-2.5; 5) untreated with dopaminergic drugs.
Exclusion criteria
Exclusion criteria: 1) secondary parkinsonism or atypical parkinsonism; 2) other neurological disorders including epilepsy, stroke and brain injury; 3) psychiatric disorders; 4) history of alcohol or drug abuse; 5) possible dementia; 6) significant current depression; 7) unable to complete MRI; 8) working memory capacity <4.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| behavioral measures;MRI measures;gut microbiota composition; | — |
Countries
China
Contacts
Public ContactZheng Ye
Institute of Psychology, Chinese Academy of Sciences
Outcome results
None listed