Cerebrovascular disease
Conditions
Interventions
test group:rt-PA and Butylphthalide
Control group:Standard dose alteplase treatment
Sponsors
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) aged 18-80 years old; 2) clinically diagnosed as acute ischemic stroke, NIHSS score 5 or more, the initial onset or previous history of ischemic stroke but no obvious complications; 3) head CT scan showed no cerebral hemorrhage; 4) the patient is eligible for thrombolytic therapy and the patient or family member agrees to have a venous thrombolytic treatment and sign an informed consent form; 5) patients receiving intravenous thrombolysis within the prescribed treatment time window; 6) agree and sign informed consent for clinical use; 7) The patients and their families can cope with the collection, preservation and follow-up of medical history data.
Exclusion criteria
Exclusion criteria: 1) Pre-existing severe liver and kidney dysfunction, cardiac dysfunction, peripheral blood disease, or suffering from other serious systemic diseases; 2) intracerebral hemorrhagic diseases seen by head CT / MRI: cerebral hemorrhage, subarachnoid hemorrhage (excluding pseudo-subarachnoid hemorrhage), etc., or diseases with hemorrhagic tendency; 3) concurrent malignant tumor or ongoing anti-tumor treatment; 4) previous history of allergy to celery or nipop; 5) Pregnancy, lactation or pregnancy may be pregnant and plan patients; 6) Participate in other interventional clinical studies or participate in other interventional clinical studies within 3 months prior to the acquisition date of informed consent; 7) Patients that researchers think are not suitable for this clinical study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score;mRS score three months after thrombolysis;CT perfusion parameters (including CBV, CBF, PS, MTT);Serological inflammation and tight junction protein indicators: MMP-2, MMP-9, TIMP-1; | — |
Countries
China
Contacts
Public ContactLiang Zhigang
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Outcome results
None listed