Breast cancer
Conditions
Interventions
Post-menopausal estrogen receptor-positive breast cancer:no
Pre-menopausal estrogen receptor-positive breast cancer:no
Pre-/post-menopausal estrogen receptor-negative breast cancer:Control group 2: Pre/post-menopausal non-malignant breast conditions
Post-menopausal healthy controls (no abnormal breast pathology, normal mammogram or ultrasonography):no
Pre-menopausal healthy controls (no abnormal breast pathology, normal mammogram or ultrasonography):no
Pre/post-menopausal non-malignant breast conditions:No
Sponsors
The Chinese University of Hong Kong
Eligibility
Sex/Gender
Female
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Chinese female; 2. Aged greater than or equal to 18 years (no upper age limit); 3. Either: with a newly (within 3 months without surgical intervention other than biopsy) suspected benign or malignant breast lesion(s) for which tissue sample has been/will be taken pathological diagnosis (regardless of the results); OR: a bilateral mammogram / ultrasonic examination of the breast has been / will be performed within 3 months of enrollment (regardless of the results); 4. Willing to complete a questionnaire on medical history, life style and health information. 5. Willing to provide clinical findings and investigation results including pathology, radiography and ultrasonography reports related to the health status of breast. 6. Willing to donate a stool sample for this study (other optional samples include urine, blood and remaining breast tissue after completing pathological investigations). 7. Willing to provide a consent for study.
Exclusion criteria
Exclusion criteria: 1. Had undergone surgical removal of part or whole breast tissue (other than biopsy); 2. Had received any treatment for malignant breast lesions including surgery, radiotherapy, chemotherapy or hormonal therapy; 3. History of any cancer (not include the current suspected/confirmed breast lesion); 4. Had received antibiotics with the last 3 weeks (can postpone stool collection to 3 weeks after completing antibiotic treatment); 5. History of inflammatory bowel diseases or diverticulitis; 6. History of gastric banding or bypass; 7. History of major gastric or intestinal surgery (not include endoscopy, biopsy, removal of polyps or haemorrhoids).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| profile of gut microbiota in hormonal receptor-positive breast cancer and controls; | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify the correlations between gut and breast tissue microbiota among women with different subtypes of breast cancer or benign conditions.;Correlate gut microbiota with level of estrogens and estrogen metabolites in urine and blood, and with breast tissue microbiota.; | — |
Countries
China
Contacts
Public ContactProf. Paul KS Chan
The Chinese University of Hong Kong
Outcome results
None listed