Placenta-mediated pregnancy complications
Conditions
Interventions
Intervention group:Aspirin intake from the first-trimester (before 12 weeks of gestation)
Control group:Aspirin intake from the second-trimester (after 12 weeks of gestation)
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Pregnant women agree to participate in the trial, sign the informed consent form, plan to deliver at Shanghai hospital without relocation plan and meet at least one of the following criteria: (1) Aged = 35 years; (2) Overweight / obesity (pre-pregnancy/pregnancy BMI = 25 kg / m2); (3) Type I or II diabetes; (4) Chronic hypertension; (5) Family history of preeclampsia (mother or sisters); (6) History of adverse pregnancy (pre-eclampsia / eclampsia / gestational hypertension), premature birth or stillbirth; (7) Proteinuria in early pregnancy, kidney disease (nephritis, nephrotic syndrome, renal insufficiency, etc.) . (8) Autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, etc.); (9) Pregnancy interval more than 8 years.
Exclusion criteria
Exclusion criteria: Pregnant women refuse to participate in the trial, or meet at least one of the following criteria: (1) Non-Shanghai childbirth or relocation plan or unable to be followed-up; (2) Serious blood diseases (thrombocytopenia, aplastic anemia, hemophilia, severe anemia (hemoglobin <60g / L), etc.); (3) Malignant tumors, cancer; (4) AIDS; (5) Aspirin allergy or long-term use of non-steroidal anti-inflammatory drugs; (6) Pregnant women themselves suffer from serious illness or mental disorders (such as schizophrenia, epilepsy); (7) Active hepatitis, Cirrhosis; (8) Organic heart disease (rheumatic heart disease, congenital heart disease, coronary heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, etc.) or heart failure; (9) Severe lung disease (active tuberculosis, pulmonary heart disease, etc.); (10) Peptic ulcer patients; (11) Accompanied by other factors that affect compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of placenta-mediated pregnancy complications; | — |
Countries
China
Contacts
Public ContactJun Zhang
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed