Minimal hepatic encephalopathy
Conditions
Interventions
Experimental Group:JianPi HuaZhuo XingNao formula plus basic treatment
Control Group:JianPi HuaZhuo XingNao formula placebo plus basic treatment
Sponsors
Dongzhimen hospital affiliated to Beijing university of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Participants should meet all the criteria that follow: 1. Diagnosed with chronic hepatitis B, referring to the Guideline [Chinese Society of Hepatology Diseases, Chinese Medical Association. The guideline of prevention and treatment for chronic hepatitis B (2010 version)]; 2. Diagnosed with hepatocirrhosis by liver ultrasound, CT, MRI or other imaging examination, or histological evidence of hepatocirrhosis (including stage 4 liver fibrosis); 3. Diagnosed with minimal hepatic encephalopathy by neurophysiology and neuropsychology test; 4. Being voluntary participants to this project, after having signed the informed consent form.
Exclusion criteria
Exclusion criteria: Participants who meet any of the following criteria should not be enrolled: 1. Aged under 18 or over 75 years; 2. HBV infection was ruled out for the primary cause of hepatocirrhosis; 3. With severe complications of hepatocirrhosis (e.g., electrolyte disorders, gastrointestinal bleeding, infections); 4. Diagnosed with a mental illness or cerebrovascular disease; 5. Has taken a sedative in the last four weeks; 6. Long-term drinkers for at least five years (equivalent to ethanol: 40g/day for male or 20g/day for female) or heavy drinkers (equivalent to ethanol: 40g/day) within two weeks; 7. Body temperature over 37.5 degree C; 8. Accompanied by cardiovascular, pulmonary, renal, endocrine, nerve and hematology diseases; 9. Diagnosed malignant tumor; 10. Can not cooperate with this research due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of developing overt hepatic encephalopathy.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number connection test A (NCT-A);Digital sign test (DST);SF-36 survey;Chronic liver disease questionnaire; | — |
Countries
China
Contacts
Public ContactLi Xiaoke
Dongzhimen hospital affiliated to Beijing university of Chinese medicine
Outcome results
None listed