malignant hematological disease
Conditions
Interventions
Case series:modified and dose-reduced BUCY
Sponsors
ZhongDa Hospital Southeast University
Eligibility
Sex/Gender
All
Age
2 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) aged 2 to 65 years; (2) absence a HLA-matched sibling donor, and/or in need of an urgent allograft; (3) at freezing, nucleated cell dose should be>2.5x107/kg and CD34 cell dose >1.2x105/kg; if the cell dose was insufficient with a single CBU, double cord blood unit was used; (4) the score of Karnofsky =60; (5) Signed written informed consent.
Exclusion criteria
Exclusion criteria: (1) Serious viscera dysfunction or disease, such as serious diseases and function disorder in heart, liver, kidney and pancreas; (2) Patients with pregnancy; (3) Participants and/or authorized family members refused to accept UCBT; (4) Researchers believe that can damage the unnecessary risks to safety, make the results of the study subjects any life-threatening illness, condition or organ system dysfunction; drug dependence; uncontrolled mental disease; cognitive impairment; (5) Researchers think that the patient doesn't fit into the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative rate of neutrophil engraftment;Cumulative rate of platelet engraftment;Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| GVHD;chimerism;relapse;TRM; | — |
Countries
China
Contacts
Public ContactDing Jiahua
Zhongda Hospital Southeast University
Outcome results
None listed