biliary atresia
Conditions
Interventions
high-dose:UDCA 25mg/kg po
low-dose:UDCA 15mg/kg po
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) within 72 hours after Kasai procedure for type III biliary atresia; 2) The gestational age at birth is = 36 weeks, male or female; 3) Weight = 2kg when selected; 4) Family members understand and sign informed consent before or during Kasai surgery.
Exclusion criteria
Exclusion criteria: 1) There is a known immune deficiency; 2) Severe surgical complications (such as intestinal obstruction, massive bleeding, etc.) occur within 72 hours after surgery or within the postoperative period; 3) With diabetes or high blood pressure (systolic blood pressure persists =112mmHg); 4) Hemolytic jaundice, ie indirect bilirubin = 85.5 µmol/L (5 mg/dL) within 4 weeks of birth, or indirect bilirubin = 119.7 µmol/L (7 mg/dL) during 4-8 weeks of birth; 5) The mother suffers from human immunodeficiency disease, or is positive for HBsAg, or is positive for hepatitis C virus; 6) Incorporate other infections (such as herpes simplex virus, Toxoplasma gondii, etc.); 7) Severely allergic to steroids or other adjunctive therapies; 8) Consolidate other serious systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| jaundice clearance rate ;native liver survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| urinary component analysis;native liver survival rate; | — |
Countries
China
Contacts
Public ContactZheng Shan
Children's Hospital of Fudan University
Outcome results
None listed