major depressive disorder
Conditions
Interventions
experimental group:light therapy combined with fluoxetine
Sponsors
Beijing Anding Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Signed consent to treatment; 2. Males and females aged 18 to 60 years; 3. have a Mini-International Neuropsychiatric Interview (MINI) confirmed diagnosis of DSM-IV criteria Major depressive Disorder without psychosis of at least moderate severity of depression, single or recurrent,HAMD-17=17; 4. Did not taken any antidepressant, mood stabilizers or antipsychotics; 5. planning to use fluoxetine.
Exclusion criteria
Exclusion criteria: 1. have a lifetime Mini-International Neuropsychiatric Interview (MINI) diagnosis of other primary psychiatric diagnoses; 2. sufferd with Retinopathy,Cataract, glaucoma, diabetes; 3. have active suicidal ideation (score of 3 = on item 3 of HAMD), OR are at a significant risk of harm to themselves or others; 4. Previous ECT treatment within 3 months; 5. have an alcohol or substance use disorder within the last 12 months; 6. have concomitant acute or chronic major medical illness,for example, cardiac disease, kidney disease, liver disease, tumor,or have any significant neurological disorder; 7. are currently pregnant , breast feeding or plan to become pregnant; 8. history of non-response to fluoxetine or allergic to fluoxetine; 9. Depressive episodes have seasonal characteristics (DSM-IV "recurrent depression with seasonal characteristics").
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the HAMD reduced score; | — |
Countries
China
Contacts
Public ContactHu Chen
Beijing Anding Hospital
Outcome results
None listed