stroke
Conditions
Interventions
control group:Bifico 4 blank capsules 2 times / day + Xinglou Chengqi Decoction 1 blank bag 2 times / day
Western medicine group:Bifico 4 capsules 2 times / day + Xinglou Chengqi Decoction 1 blank bag 2 times / day
Combine traditional Chinese and medicine treatment group:Bifico 4 capsules 2 times / day + Xinglou Chengqi Decoction 1 bag 2 times / day
Sponsors
Beijing Friendship Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria for acute ischemic stroke in Western Medicine: (1) sudden onset; (2) Focal nerve function defect; (3) The brain CT or MRI proved a new cerebral infarction. 2. The standard of diagnosis of phlegm and heat of Chinese Medicine: hemiparalysis, the deviation of the mouth, the stiff tongue, dysphasia or aphasia, hypoesthesia or anesthesia,dizziness and headache, coughing up phlegm or excessive phlegm, abdominal distention, dry stool and constipation, dark red in tongue proper,greasy and yellow fur on the tongue, wiry and rolling pulse or lateral chord slippery and large; 3. NIHSS score 4-15 in patients with moderate nerve function injury; 4. The age is 18-75 years old, and the male and female are not limited; 5. The patients will volunteer for the research and will sign the informed consent (patient or legal agent)
Exclusion criteria
Exclusion criteria: (1) Transient ischemic attack; (2) Hemorrhagic brain injury, such as cerebral hemorrhage, subarachnoid hemorrhage, subdural hemorrhage, epidural hemorrhage, etc.; (3) intracranial spaceoccupying lesions; (4) Patients with previous digestive diseases, including constipation, diarrhea, alimentary tract ulcers, gastrointestinal bleeding, ulcerative colitis, etc.; (5) In the past 1 months the patients take test medication (Bifico and xinglouchengqi decoction); (6) The patients who are allergic to the ingredients of the Experimental drug; (7) The patinets use antibiotics before and after treatment; (8) Patients with serious diseases such as heart, kidney, liver, hematopoietic system and immune system are excluded; (9) Cancer patients and patients with mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6 levels in blood;IL-10 levels in blood;TNF-a levels in blood;Separation of peripheral blood mononuclear cells by flow cytometry;Analysis of the expression of PBMC transcriptional level and screening of differentially expressed genes by the sequencing of RNA-seq transcriptome;Detection of intestinal microbes in feces by high throughput 16rRNA sequencing;NIHSS score;Barthel index score; | — |
Countries
China
Contacts
Public ContactYingying Zhao
Beijing Friendship Hospital affiliated to Capital Medical University
Outcome results
None listed