Cognitive impairment after cerebral infarction
Conditions
Interventions
Experimental group:limb ischemia postconditioning+conventional neuroprotective treatment
control group:conventional neuroprotective treatment
Sponsors
Henan Province People's Hospital of Internal Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. all patients met the criteria for the diagnosis of cerebral infarction [21] and confirmed on diffusion-weighted magnetic resonance imaging (DWI) that there was a new lesion; 2. Aged 40 to 80 years old; 3. with onset within 72 hours, first onset, or re-onset, but a mRS score of 0-1 before the onset of the disease. Previous sequelae did not affect the neurological function score; 4. patients and their families had signed informed consent after informed consent.
Exclusion criteria
Exclusion criteria: 1. intracerebral hemorrhage or other active hemorrhagic diseases; 2. within 72 hours of thrombolytic therapy by arterial or venous thrombolytic; 3. therapy: previous history of arteriovenous malformation, internal carotid aneurysm, history of brain neoplasms, history of brain surgery, Severe heart failure, acute myocardial infarction; 4. pericarditis, infective endocarditis or suspected infective emboli, aneurysms of the heart wall, Ventricular Thrombosis etc.; 5. severe liver or kidney diseases: malignant neoplasms; systemic organ failure; 6. Clinical examination: unconscious NIHSS > 25; severe aphasia, severe aphasia, severe aphasia, Unable to express yourself; 7. dementia or mental illness; 8. pregnancy; 9. MRI contraindications; 10. blood glucose 22 mmol/L; 11. blood pressure > 200/110 mmHg or < 90/60 mm Hg1; 12. can't be combined with the Montreal cognitive Assessment scale and the MMSE scale to evaluate the limbs; 13. Poor compliance with post-treatment or failure to provide informed consent; 14. Refusal of regular treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| infarct volume;National Institute of Health stroke scale;mRS;stroke cases;Death; | — |
Countries
China
Contacts
Public ContactZHAO Jianhua
Henan Province People's Hospital of Internal Medicine
Outcome results
None listed