Postoperative Sore Throat
Conditions
Interventions
group F:aerosol inhalation of furosemide 40mg
group B:aerosol inhalation of budesonide 2mg
Sponsors
Plastic Surgery Hospital, The Chinese Academy of Medical Sciences, Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists (ASA) Class I-II, Aged 18-55 years, Normal body mass index range (18.5-23.9 kg / m2), Mallampatti grade 1-2, No respiratory/ circulatory complications, Normal pulmonary functionNormal hepatic and renal function, Patients will be selected for general anesthesia through the nasotracheal intubation undergoing cranial and maxillofacial surgery, Patients able to provide written informed consent and to fulfil study request.
Exclusion criteria
Exclusion criteria: Patients with history of respiratory tract infection within 2 weeks, Oral and ENT diseases and surgical history, Knot hoof tissue disease, Diabetes mellitus. Expected difficult airway and intubation, twice or more intubated patients, Preoperative and intraoperative use of anticholinergic drugs, non-steroidal anti-inflammatory drugs or hormone drugs, Change the patient's position and surgical approach temporarily in progress, Test drug allergy, Patients who cannot tolerate aerosol inhalation, With reading or communication disorders, Unsuitable for the study for every other reasons, in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperation throat pain;hoarseness of voice;foreign body sensation in oropharyngeal area; | — |
Secondary
| Measure | Time frame |
|---|---|
| xerostomi;nausea;Vomiting;Pain site of postoperative sore throat;cough; | — |
Countries
China
Contacts
Public ContactAn Jie
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed