nasopharyngeal darcinoma
Conditions
Interventions
Case series:The first day of radiotherapy, oral Rabdosia Rubescens drop pills
Regular use of sodium bicarbonate gargle, but keep a detailed record
When pain level 2 is reached, Lidocaine is given for pain relief, but detailed records are required
Sponsors
Sichuan Provincial Tumor Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Willingness to participate in the trial and sign the informed consent file; (2) Aged 18 and 70 years male or female; (3) Nasopharyngeal carcinoma with no distant metastasis was confirmed by histopathology; (4) The patients with stage I, II, III, IVA, IVB in the clinical stage of nasopharyngeal carcinoma in the eighth edition of AJCC were diagnosed as stage I, II, III, IVA, IVB; (5) Radical radiotherapy and chemotherapy were scheduled (IMRT technique was used for radiotherapy and cisplatin regimen was used for chemotherapy; (6) KPS = 70 (see Annex I); (7) The life expectancy is at least 6 months.
Exclusion criteria
Exclusion criteria: (1) There are active oral infections, including candida oropharyngii and facial herpes, or other oral diseases; (2) Elderly patients with dry stomatitis; (3) Recurrent or residual nasopharyngeal carcinoma; (4) Patients undergoing chemotherapy with 5-fluorouracil regimen; (5) Patients receiving simultaneous molecular targeting therapy; (6) Patients with severe heart, liver, kidney, hematopoietic and nervous system diseases, psychosis, diabetic patients with unsatisfactory blood glucose control; (7) Allergic physique, known or suspected to be allergic to this test drug; (8) Pregnant, lactating women, and women of childbearing age that can not effectively contraception during the trial period; (9) Those who have participated in clinical trials of other drugs within 3 months; (10) Alcohol and/or drug abusers; (11) There are other researchers who do not consider it appropriate to take part in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the onset time of grade I, II, III oral mucositis by CTCAE3.0; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and degree of oral pain;CRP;T-cell subsets and NK cells;Nutrition risk screening 2002; | — |
Countries
China
Contacts
Public ContactJinyi Lang
Sichuan Provincial Tumor Hospital
Outcome results
None listed