newly diagnosed high-risk adult PH (-) B-ALL
Conditions
Interventions
case series:CD19+CART cells+chemotherapy
Sponsors
Department of hematology, Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. newly diagnosed adult ph negative high-risk B-ALL patients with below condition; 2. Aged from 18 to 65 years; 3. ECOG score =2; 4. The Prognostic stratification at high risk, and the PH negative, not suitable for allogeneic stem cell transplantation or the rejection of allogeneic stem cell transplantation due to other reason; 5. No significant organ dysfunction.
Exclusion criteria
Exclusion criteria: 1) relapse ALL, CNS-ALL; 2) pregnant and lactating women; 3) participate clinical trials of other new drugs within 3 months; 4) abnormal liver and kidney function,which defined as 1.5 times higher than the upper limit of serum transaminase and bilirubin.Creatinine exceeds the normal upper limit; 5) patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Surviva;Progress Free Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Response;minimal residual disease;toxic and adverse effects; | — |
Countries
China
Contacts
Public ContactZhao mingfeng
Department of hematology, Tianjin First Central Hospital
Outcome results
None listed