renal cancer
Conditions
Interventions
Case series:neoadjuvant stereotactic radiotherapy
Sponsors
Department of Urology, Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged = 18 years; 2. Radiographic evidence of renal cancer with inferior vena cava(IVC) tumor thrombus; 3. Tumor thrombus must be = Mayo Level II; 4. Patient eligible for stereotactic radiotherapy(SBRT) to the IVC tumor thrombus as decided by the treating radiation oncologist; 5. Patient eligible for IVC tumor thrombectomy as decided by the treating urologist; 6. Performance status ECOG 0-2; 7. Subjects must be able to undergo either a contrast enhanced MRI or CT; 8. Ability to understand and the willingness to sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects who have had radiotherapy to area of renal cancer or IVC tumor thrombus; 2. Subjects may have received targeted therapy, chemotherapy or any other investigational agents; 3. Subjects with a history of pulmonary embolism are excluded; 4. Subjects who are unable to tolerate SBRT or operation are excluded, such as severe cardiopulmonary insufficiency, severe arrhythmia, myocardial infarction, angina pectoris, severe coagulant disease, severe liver disease and so on; 5. Subjects who had eriously affecting the patient's judgement of disease are excluded, such as psychosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mayo level of tumor thrombus;length of the corresponding anatomical mark of the tumor thrombus;Inferior vena cava wall invasion;Adverse reaction of SBRT in 4-6 weeks;Relapse-free survival;cancer-specific survival;overall survival;Perioperative complications;operation time;Intraoperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| The longest diameter of the tumor;node status; | — |
Countries
China
Contacts
Public ContactMa Lulin
Peking University Third Hospital
Outcome results
None listed