liver transplantation
Conditions
Interventions
experimental group and control group:The patients with liver transplantation within 3 years of age and below were selected before surgery for Cylex ATP as the baseline value. After liver transplantati
Sponsors
Renji Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: 1. the patient's family members voluntarily signed informed consent and have been verbally informed of specific test programs; 2. Chinese nationality; 3. children younger than 3 years old with primary liver transplantation.
Exclusion criteria
Exclusion criteria: 1. the combination of drugs containing drugs that affect CYP3A activity, such as erythromycin, itraconazole and so on; 2. other research drugs were used within 4 weeks before enrollment; 3. transplant or multiple organ transplant children again; 4. suffering from severe anemia, severe malnutrition, intestinal absorption disorders affect drug metabolism disease, or other surgical complications were judged by the researchers as follow-up assessment of the impact of the study; 5. the initial medication for other CNI drugs, into children with tacrolimus; 6. the use of tacrolimus or cyclosporine serious adverse reactions need to switch other immunosuppressive agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute rejection. (biopsy proven or clinical AR);Percentage of transplant-related infectious diseases occurred; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of Cylex ATP results with immunosuppressive efficacy (stabilization / rejection / infection);Survival of patients and grafts; | — |
Countries
China
Contacts
Public ContactXia Qiang
Liver Surgery Department, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed