Chronic Obstructive Pulmonary Disease
Conditions
Interventions
early COPD group:none
early ACO group:none
non-early COPD group:none
Sponsors
National Clincial Research Center of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged =40 years old; 2. Persistent airflow limitation (post-bronchodilator FEV1/FVC value <0.70); 3. Signed informed consent form; 4. Female patients need contraception.
Exclusion criteria
Exclusion criteria: 1. Respiratory diseases (1) Patients with a history of alpha-1 antitrypsin deficiency or were diagnosed with a deficiency of alpha-1 antitrypsin; (2) Other respiratory diseases, such as active pulmonary tuberculosis, bronchiectasis with clinical significance, lung cancer, and huge pulmonary bullous, interstitial pulmonary fibrosis, primary pulmonary hypertension, uncontrolled sleep apnea syndrome; (3) Lung volume reduction: lung volume reduction, lobectomy or bronchoscopy,etc; (4) Chronic obstructive pulmonary disease or asthma condition is poorly controlled: hospitalized for acute exacerbation within 4 weeks prior to screening. 2. Circulatory diseases (1) Patients with unstable ischemic heart disease, left heart failure, coronary heart disease or myocardial infarction; (2) Congestive heart failure; (3) Arrhythmia (tachycardia, atrial fibrillation, atria); (4) ST-T wave anomaly; (5) Uncontrolled hypertension (systolic pressure > 180mmHg, diastolic blood pressure > 100mmHg). 3. Nervous system (1) Hstory of convulsions and epilepsy; (2) Patients with cerebrovascular accident (cerebral apoplexy, persistent cerebral hemorrhage, etc.) during the first 6 months of the screening period. 4. Endocrine (1) Uncontrolled hyperthyroidism or hypokalemia. 5. According to the researcher's judgment, the subjects who were not suitable for the study were not suitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary fuction;Low dose double - phase helical CT.;Symptom assessment questionnaire; | — |
Countries
China
Contacts
Public ContactJingping Zheng
National Clincial Research Center of Respiratory Disease,The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed