Schizophrenia
Conditions
Interventions
Sponsors
Department of Psychiatry, Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for schizophrenia were the following: 1) the biological parents of the patients were all Han Chinese, conforming to the criteria for schizophrenia of the Diagnostic and statistical manual of mental disorders, 5th edition, DSM-V; 2) the score of the positive and negative symptom rating scale was greater than 60 in the first-episode patients with schizophrenia; 3) had to be right-handed:the questionnaire was based on 10 questionnaires from Edinburgh; 4) aged 18 and 55 years; 5) informed consent of the patient or family member. The inclusion criteria for healthy controls: 1) age, gender and education pair-matched with schizophrenia patients; 2) they are healthy and right-handed and biological parents are Han-Chinese; 3) there is no blood relationship between individuals and the aged 18 and 55 years; 4) they voluntery or their family agree to join in the trial.
Exclusion criteria
Exclusion criteria: 1) had other psychiatric history including schizoaffective disorder, mood disorder, mental retardation, dementia; 2) had a history of alcohol or substance abuse; 3) had history of diabetes, thyroid disease, hypertension, cardiopathy; 4) presented with chronic neurological disorders; 5) had contraindications to MRI scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genotype;Amplitude of low-frequency fluctuation;fractional anisotropy;mean diffusivity;axial diffusivity;radial diffusivity components; | — |
Countries
China
Contacts
Public ContactGuoda Ma
Department of Psychiatry, Affiliated Hospital of Guangdong Medical University
Outcome results
None listed