thyroid associated ophthalmopathy
Conditions
Interventions
1:orbital radiation therapy
2:methotrexate
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 30-60 years old, no restriction for gender; 2. Diagnosed with moderate-severe TAO in active phase; 3. Normalized thyroid function for at least 1 months before included: including those who are taking anti hyperthyroidism drugs or without taking medication, FT3, FT4 normal, TSH normal or lower; 4. Body weight between 40-70 kg; 5. Informed consent signed; 6. Glucocorticoid treatment accumulative 4.5g insensitive.
Exclusion criteria
Exclusion criteria: 1. Severe disease of heart, liver and kidney function failure including myocardial ischemia or myocardial infarction, arrhythmia and heart failure; ALT, AST more than 1.5 times the upper limit of the normal value; limit; creatinine level over normal limit or eGFR < 60 ml/min/1.73 M2); 2. Gastric ulcer, gastric bleeding, diabetes or other autoimmune diseases, uncontrolled hypertension, tuberculosis, mental disease patients, glaucoma, diabetes, HIV infection or AIDS patients; 3. Patients allergic to glucocorticoid or methotrexate; 4. Patients with pregnancy test, in lactation; 5. Patients who received radioactive iodine therapy, vaccination hepatitis vaccine 3 months before the study; 6. Patients who received the systemic immunotherapy for TAO, including oral or intravenous corticosteroids, other immunosuppressive agents and orbital radiation, etc., 1 month before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Efficacy Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Activity Score; | — |
Countries
China
Contacts
Public ContactZhou Huifang
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed