ventilator-induced lung injury
Conditions
Interventions
VO:Volume control One-lung ventilation
VD:Volume control Double lung ventilation with artificial pneumothorax
PO:Pressure control One-lung ventilation
PD:Pressure control Pressure control
Sponsors
First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Preoperative heart and lung function of liver and kidney disease; 2.No history of alcoholism; 3.Quit smoking more than 2 weeks before surgery; 4.No infection within a week before surgery, no history of antibiotic use; 5.The tumor is located in the lower esophagus; 6.Preoperative pulmonary function test results: MVV measured / expected value = 70%, FEV1% = 60%, the diffusivity 7.DLCO measured / expected value = 60%.
Exclusion criteria
Exclusion criteria: 1.Patients or their families do not sign an informed consent form; 2.Preoperative ASA grade in grade ? or more; 3.Hypoproteinemia; 4.Difficult airway; 5.Preoperative existence of acute upper respiratory tract disease or COPD, asthma and other lung dysfunction disease; 6.Preoperative existence of hypertension, coronary heart disease, arrhythmia and other cardiovascular diseases, diabetes and other metabolic diseases; 7.Preoperative use of corticosteroids, tricyclic antidepressants; 8.Preoperative radiotherapy and chemotherapy treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDA;SOD; | — |
Countries
China
Contacts
Public ContactDao Xiang
First Affiliated Hospital of Zhengzhou University
Outcome results
None listed