stable angina
Conditions
Interventions
TMZ group: A dose of 35mg oral TMZ is administered during 2 times of meal a day besides conventional treatments in TMZ group for 3 months.
Control group:Routine treatment
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. more than 60 years of age; 2. ICF signature confirmed; 3. low HS (<26.0kg for men and <18.0kg for women) or low GS criterion (<0.8m/s) [9-10]; 4. stable angina criterion (a history of Coronary artery disease (CAD) diagnosed by coronary artery angiography, computed tomography angiography or treadmill test and the same cause, nature, location, duration, remission and frequency of angina during past 3 months)
Exclusion criteria
Exclusion criteria: 1. secondary hypertension; 2. secondary poor muscle strength or physical performance, including New York Heart Association class III to IV heart failure; 3. operation in the past 3 months or poor exercise performance caused by neurological diseases, musculoskeletal diseases or pain; 4. liver or renal dysfunction; 5. diagnosed thyroid diseases; 6. diagnosed hematological diseases; 7. diagnosed unhealed tuberculosis or metastatic advanced tumor or malignant tumor discovery less than 5 years; 8. being hypersensitive to TMZ contents or having taken TMZ in the past 3 months; 9. failure of cooperation because of other comorbidities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-minite walking distance (6MWD) change; | — |
Secondary
| Measure | Time frame |
|---|---|
| handgrip strength;pinch strength;gait speed (GS);Five Times Sit-to-Stand Test (FTSST);; | — |
Countries
China
Contacts
Public ContactLi Xiaoying
Chinese PLA General Hospital
Outcome results
None listed