acute respiratory distress syndrome
Conditions
Interventions
control group:normal saline 100ml, ivdrip
MSC group:hucMSCs 10^6/kg+N.S 100ml, ivdrip
Sponsors
The Third Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged=18 years old; 2. Including all the criteria: (1) Invasive ventilation, OI(PaO2/FiO2)<200; (2) PEEP=8cmH2O; (3) Bilateral inflitration of lung in X-ray or CT; (4) In 1 week after onset; (5) Still OI<200 after protective ventilation or conservative fluid management.
Exclusion criteria
Exclusion criteria: (1) Any malignant disease; (2) Cardiogenic pulmonary edema; (3) Over 50% atelectasis either lung lobe in X-ray; (4) Pregnancy or perinatal or lactation; (5) Previous end stage respiratory disease; (6) More than 3 organs failure; (7) Liver failure with MELD score>40; (8) Stage III or IV pulmonary hypertension; (9) None invasive arterial and central venous catheter; (10) Concurrent deep venous thrombus or pulmonary embolism in 3 months; (11) Cerebral hernia; (12) More than 96 hours after ARDS onset.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilation free days(VFDs);Oxygenation index change; | — |
Countries
China
Contacts
Public ContactHaijin Lv
The Third Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed