general anesthesia
Conditions
Interventions
A:Remifentanil TCI 6.0 ng / ml
B:Remifentanil TCI 12.0 ng / ml
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Informed consent; 2. Aged 18~65 years old, male or female; 3. ASA I~II; 4. BMI between 18kg/m2 to 30kg/m2; 5. Elective thoracoscopic surgery under general anesthesia, expected operation time of 90 minutes or more.
Exclusion criteria
Exclusion criteria: 1. The central nervous system disease; 2. Using any drugs known to affect EEG preoperative such as antipsychotics, sedatives, anti-epileptic drugs, central nervous system stimulants, including alcohol; 3. Allergy to any ingredient of propofol and remifentanil; 4. The emergency surgery; 5. Implanted electronic devices, for example, a patient fitted with a pacemaker, etc; 6. Pregnant women and lactating women; 7. Serious cardiovascular, respiratory,kidney,adrenal, hypothalamic pituitary or muscle disease history; 8. Abnormal liver function,Renal dysfunction,Coagulation dysfunction; 9. Inappropriately controlled or difficult to controlled hypertension: non-invasive systolic blood pressure (SBP) >=160mmHg or non-invasive diastolic blood pressure (DBP) >=100mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| global score;Serum ACTH, epinephrine, norepinephrine, cortisol and TNF-?, IL6, IL10 concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of Satisfaction anesthesia time;The hemodynamic status during anesthesia induces and maintains; | — |
Countries
China
Contacts
Public ContactMingzhang Zuo
Beijing Hospital
Outcome results
None listed