bronchiectasis
Conditions
Interventions
Group 1:bi-level positive airway pressure + use high-frequency ventilation
Group 2:use bi-level positive airway pressure ventilation
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years old; 2. Bronchiectasis diagnosed by physician; 3. Combined respiratory failure or dyspnea(PaO2?60mmHg or PaCO2=50mmHgwith or without acidemia or mMRC Dyspnea Scale=2.
Exclusion criteria
Exclusion criteria: 1. new or increased hemoptysis; 2. Combine with sleep-disordered breathing disease; 3. different degrees of disturbance of consciousness; 4. Hemodynamically unstable, such as acute left heart failure, unstable angina; 5. Combined with other respiratory diseases (asthma, pulmonary fibrosis, sleep apnea, airway tumors, tuberculosis sequelae, etc.); 6. Combine with cancer, diabetes or other chronic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In Vitro Sputum Cough Clearability;Sputum Volume;Wettability by Contact Angle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas;Lung function;Respiratory resistance at the end of the Flexo test;Respiratory resistance by Flexo at the end of test Rales analysis by FFT with Matlab after cough;mMRC Dyspnea Scale;Short-term non-invasive ventilation resistance rate;Acute exacerbations require invasive mechanical ventilation.; | — |
Countries
China
Contacts
Public ContactDedong Ma
Qilu Hospital of Shandong University
Outcome results
None listed