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Epidural and Intrathecal Dexmedetomidine and Sufentanil for Labor Analgesia: a Prospective, Double-blind, Randomized Control Clinical Study

Epidural Dexmedetomidine and Sufentanil for Labor Analgesia; Comparative Effects of Single-shot Intrathecal Dexmedetomidine and Sufentanil Combined with Epidural Ropivacaine in Labour Analgesia: a Prospective, Double-blind, Randomized Control Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800014943
Enrollment
Unknown
Registered
2018-02-23
Start date
2018-03-01
Completion date
Unknown
Last updated
2019-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor pain

Interventions

Group RD:Group RD received 0.1% ropivacaine plus 0.5 µg/ml dexmedetomidine epidurally
Group RS:Group RS received 0.1% ropivacaine plus 0.5 µg/ml sufentanil epidurally
Group RDS:Group RDS received 0.1% ropivacaine plus 0.25 µg/ml dexmedetomidine and 0.25 µg/ml sufentanil epidurally
Group C:Intrathecal drug injection: 1 ml sodium (0.9%) , then combined with an epidural of 0.1% ropivacaine+0.2 µg/ml sulfentanil
Group D:GroupD were injected with 5 µg dexmedetomidine intrathecally, then combined with an epidural of 0.1% ropivacaine+0.2 µg/ml sulfentanil
Group S:Group S were injected with 5 µg sufentanil intrathecally, then combined with an epidural of 0.1% ropivacaine+0.2 µg/ml sulfentanil

Sponsors

Anesthesiology Department, Shenzhen Maternal and Child Health Care Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant women who are expected to undergo vaginal delivery during the period of 35 to 42 weeks; ASA I - II

Exclusion criteria

Exclusion criteria: Coagulant function abnormality or there are other contraindications of intra-spinal anesthesia

Design outcomes

Primary

MeasureTime frame
VAS;

Secondary

MeasureTime frame
the onset time;the duration of each labor stage;Apgar score;the mode of delivery;the bolus times, total volume of anesthetic solution;the motor blockade level;the side effects;

Countries

China

Contacts

Public ContactGehui Li

Anesthesiology Department, Shenzhen Maternal and Child Health Care Hospital

gehuilidoctor@163.com+86 15012680186

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026