Alzheimer's disease
Conditions
Interventions
1:simvastatin 40mg po qn
2:placebo 40mg po qn
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
50 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Ages 50~65 years male and female; 2. In the last 30 days, serum lipid level in the morning was consistent with the diagnostic criteria of hypercholesterolemia at least twice, that is total serum cholesterol concentration = 5.18 mmol/L and (or) serum low-density lipoprotein cholesterol concentration = 3.37 mmol/L; 3. Without contraindications to simvastatin; 4. The provision of informed consent for study participation.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Secondary hyperlipidemia; 3. Taking lipid-lowering drugs or other drugs which could affect both lipid and plasma biomarkers in last 14 days; 4. Allergic constitutions or be allergic to statins; 5. Heavy drinking, active hepatitis and patients with unexplained elevated aminotransferase; 6. Non-cooperative individuals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aß1-40;Aß1-42; | — |
Secondary
| Measure | Time frame |
|---|---|
| sLRP1;sRAGE; | — |
Countries
China
Contacts
Public ContactQu Qiumin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed