general anesthesia
Conditions
Interventions
Case Group:general anesthesia
Control group:No
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: Experimental group: 1. Aged 0 month to 3 years twins; 2. ASA I-III; 3. Estimated time of Anesthesia exposure 3~6 hours; 4. Living in the city where the study site located; 5. Sign the informed consents. Control group: twin baby without surgery and anestehsia.
Exclusion criteria
Exclusion criteria: 1. Premature infants with gestational age less than 36 weeks, or developmental, cognitive or behavioral abnormalities were found based on the preoperative screening; 2. Known congenital malformations which might have potential impact on the development of neurological function; 3. Known central nervous system disorder based on the DSM diagnostic criteria; 4. History of asphyxia; 5. Children undergoing cardiac or neurological surgery; 6. Children with malignant tumor with estimated survival time less than five years; 7. Children who have contradictions to inhalation anesthesia or general anesthesia; 8. The mother of the child had history of general anesthesia during pregnancy, or the child had a history of over 1 hours of anesthesia before the study or had more than two times of anesthesia; 9. Communicating difficulty with the guardian; 10. preoperative Developmental Screening Test (DST)< 85.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At the age of 5, the Wechsler Intelligence Scale for children, Four Edition (WPPSI-IV) was used to evaluate to IQ total score;The Wechsler children’s Intelligence Scale (Fourth Edition, WPPSI-IV) could assess different cognitive dimensions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ages & Stages Questionnaires Third Edition (ASQ-3) to evaluate the differences of neuropsychological development between the two groups at every 0.5 year age increase until 5 years old after surgery;Achenbach's preschool Child Behavior Checklist 4-6(CBCL4-6) completed by parents or caregiver of the children at 4 and 5 years of age;Correlation of surgical type, operation time, age of surgery and gender with postoperative neurocognitive development; | — |
Contacts
Public ContactZuo Yunxia
Department of Anesthesiology, West China Hosptial, Sichuan University
Outcome results
None listed