Refractory Rheumatoid Arthritis
Conditions
Interventions
Traditional treatment group:Basic treatment+NS+laser radiation
PDT once group:Basic treatment+photosensitizer+laser radiation for one time
PDT twice group:treatment+photosensitizer+laser radiation for two times
Sponsors
Integrated Hospital of Traditional Chinese Medicine, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male or female pts (aged between 18 and 70 years) ; 2. Patients who meet the diagnostic criteria for RRA; 3. Patients with at least one side knee swelling for one month; 4. Patients with synovial hyperplasia confirmed by ultrasound or MRI: UCSS more than 2 points and/or single-site MR scores more than 2 points; 5. Patients capable of signing the informed consent and able to complete the experiment as required; 6. Patients with good compliance and who will complete follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with serious primary diseases such as those affecting the cardiovascular, liver, kidney, brain or haematopoietic system; 2. Patients with infection and abnormal coagulation function; 3. Breast-feeding and pregnant women; 4. Patients allergic to anaesthetics and photosensitive drugs; 5. Patients injected with intra-articular drug in one month; 6. Patients with arthritic knee joints with osteotropic ankylosis indicated by X-ray.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Ultrasound Compound Score of Synovitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| DAS28 score;RF;Anti CCP antibody;ESR;CRP;Histopathological evaluation;Joint X-ray;Clinical evaluation of knee joint; | — |
Countries
China
Contacts
Public ContactChanghong Xiao
Integrated Hospital of Traditional Chinese Medicine, Southern Medical University
Outcome results
None listed