acute non-ST-elevation myocardial infarction
Conditions
Interventions
ticagrelor group:180mg loading dose of ticagrelor, followed by 90mg q12h.
TEG-optimizaed clopidogrel group: 600mg loading dose of clopidogrel, with TEG-guided upstream tirofiban, followed by clopidogrel 75mg/day
intensive statin group:Rosuvastatin of 20mg are given twice in the first 24 hours, followed by 20mg/day
low-dose statin group:Rosuvastatin are given 5mg/day
Sponsors
Tianjin Cardiogy Institue
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between from 18 to 75 years; 2. diagnosed of acute NSTEMI; 3. early PCI within 24 hours is planning according to China PCI guideline in 2016; 4. Severe stenostic or thrombotic lesions in epicardial coronary arteries.
Exclusion criteria
Exclusion criteria: 1. Urgency PCI with 2 hours is indicated, including hemodynamic compromise or cardiogenic shock; refractory angina; malignant arrhythmia; mechanical complications; acute heart failure; transient ST segment elevation; 2. P2Y12 receptor antagonists and/or intensive statin have been used within the 30 days before; 3. Indicators of anticoagulants; 4. Hepatic and renal dysfunction (serum creatinine>221umol/L, AST/ALT above the 5 times of upper limit, or history of cirrosis); 5. Complications of severe infection or malignant neoplasm; 6. Active digestive ulcer, anemia, coagulant dysfunction, or hypersensitive to drugs in this trial; 7. Hematopoitic system disease; 8. History of ischemic or hemorrhagic stroke.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovasular mortality;stent thrombosis;recurrent myocardial infarction;urgent revascularization;ischemic stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| CK-MB;serum soluble CD40L;MA-ADP; | — |
Countries
China
Contacts
Public ContactJingjin Che
the Second Hospital of Tianjin Medical Unniversity
Outcome results
None listed