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Effect of Protective ventilation with a high versus low inspiratory oxygen fraction on postoperative pulmonary complications

Effect of protective ventilation with a high versus low inspiratory oxygen fraction on postoperative pulmonary complications:single-center,prospective,randomized and controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800014901
Enrollment
Unknown
Registered
2018-02-13
Start date
2018-03-01
Completion date
Unknown
Last updated
2019-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pulmonary complications

Interventions

Low FiO2 group:0.3 FiO2
High FiO2 group:0.8 FiO2

Sponsors

West China Hospital,Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age=18 years; 2. ASA classification 2-3; 3. Planned abdominal surgery> 2 hours; 4. Undergoing abdominal surgery and general anaesthesia expected to be extubated; 5. Written inform consent.

Exclusion criteria

Exclusion criteria: 1. Refused to cooperate or be inappropriate; 2. Acute lung injury or acute respiratory distress syndrome in last three months; 3. Having serious heart,brain,lung,liver or kidney illness; 4. BMI >30Kg/m2; 5. Pregnant or breast-feeding; 6. Requiring re-operation or postoperative ventilation/circulation supports; 7. Participation in another experimental protocol at the time of intervention selection.

Design outcomes

Secondary

MeasureTime frame
Surgical site infection;Postoperative nausea and vomiting;Postoperative mortality;Postoperative sepsis;Postoperative septic shock;Postoperative myocardial ischemia;Postoperative heart failure;Postoperative acute kidney injury;Postoperative urinary system infection;Postoperative anastomotic fistula;Postoperative reintubation;Postoperative non-planed transferred to ICU;Length of Hospital Stay;the severity grade of postoperative pulmonary complications;

Primary

MeasureTime frame
Postoperative pulmonary complications, include respiratory failure, respiratory infection, pleural effusion, atelectasis, pneumothorax, bronchospasm, aspiration pneumonitis, pulmonary embolism;

Countries

China

Contacts

Public ContactHai Yu

West China Hospital, Sichuan University

706603748@qq.com+86 18980601548

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 1, 2026