bacterial vaginosis
Conditions
Interventions
Study Group:Treated with probiotics
Control Group: Treated with metronidazole gel
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Women aged 18-60 years with a history of sexual (2) Participate in the study voluntarily (3) Pregnant women of childbearing age were negative in urine pregnancy test and could insist on contraception during the trial period; (4) Patients meeting with the diagnostic criteria of bacterial vaginosis (Amsel standard).
Exclusion criteria
Exclusion criteria: 1) Pruritus and pain caused by Behcet's disease, diabetes mellitus; vulvovaginitis caused by pelvic inflammation; 2) Trichomoniasis vaginitis, fungal vaginitis, gonococcus, chlamydia trachomatis, vaginitis and pelvic inflammation caused by herpes simplex virus or human stinger virus; 3) Serious primary diseases such as severe cardiovascular and cerebrovascular diseases, history of abnormal liver and kidney function, hematopoietic system, etc.; 4) Pregnant, breast-feeding, and women have pregnancy plan; 5) Long-term use of antimicrobial agents; 6) Patients who need to be treated with other antifungal drugs; 7) Allergic constitution or known allergic to metronidazole; 8) Patients treated with HRT (hormone use); 9) Patients who received antifungal and microbiological therapy (systemic or intravaginal) within 2 weeks of treatment in this study; 10) Suspected malignant neoplasms or other serious diseases; 11) Patients with severe immunodeficiency or immunosuppressant use; 12) Severe liver and kidney diseases, or the level of Alt or Cr in blood is higher than the upper of normal range; 13) Patients who need treatment for cervical intraepithelial neoplasia and acute cervicitis; 14) Menstruating women; 15) Persons known to have a history of drug and alcohol abuse; 16) The researchers found that they were not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leucorrhea smear microscopic examination;Nugent Score; | — |
Countries
China
Contacts
Public ContactQu Hong
Beijing Chao-yang Hospital, Capital Medical University
Outcome results
None listed