Acute coronary syndrome
Conditions
Interventions
Group 3:clopidogrel plus rivaroxaban
Group 1:aspine plus clopidogrel
Group 2:aspine plus rivaroxaban
Sponsors
Tianjin Union Medical Center
Eligibility
Sex/Gender
All
Age
75 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged =75 years old; 2. Persistent non-valvular atrial fibrillation; 3. unstable angina or Non-st elevation myocardial infarction; 4. without revascularization patients.
Exclusion criteria
Exclusion criteria: (1) the history of hematopathy; (2) unexplained fever (> 37. 5 ?) or severe infection; (3) unbalanced electrolyte and acid-base imbalance; (4) severe liver and renal insufficiency; (5) patients with active infectious diseases; (6) severe cerebrovascular disease cannot be combined with treatment; (7) allergic to aspirin, clopidogrel and rivaroxaban; (8) surgery history or trauma history within 1 month; (9) the international standardized rate (INR)>2.5 in the treatment of hemorrhage or warfarin; (10) significant aortic valve insufficiency; (11) merge aortic dissection; (12) pregnant swomen and patients with mental illness; (13) emergency or elective coronary artery bypass grafting; (14) patients with previous myocardial infarction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| left ventricular ejection fraction;Estimate pulmonary artery pressure;Load cardiac ultrasound;six-minutes walking test;NT-ProBNP;D-dimer;inflammatory factor;oxidative stress;Coagulation related indicators; | — |
Countries
China
Contacts
Public ContactPANG ZHIHUA
Tianjin Union Medical Center
Outcome results
None listed