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The effect of antipsychotic on first-onset drug-naive schizophrenia: brain image, DNA methylation and gene expression study

The effect of antipsychotic on first-onset drug-naive schizophrenia: brain image, DNA methylation and gene expression study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800014844
Enrollment
Unknown
Registered
2018-02-08
Start date
2012-10-01
Completion date
Unknown
Last updated
2018-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

Patients:Risperidone

Sponsors

The Second Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 37 Years

Inclusion criteria

Inclusion criteria: All patients were drug-naive and were experiencing their first episode psychosis when enrolled to this study. They were diagnosed according to the Structured Clinical Interview for DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, forth edition, American Psychiatric Association, 2000), patient version (SCID-I/P), and all patients met the diagnostic criteria for schizoprenia. Patients had an onset age from 18 to 40 years, and had less than 1 year duration of disease. All participants were Chinese Han people and right-handed.

Exclusion criteria

Exclusion criteria: Participants with a history of neurological illness, physical disorders or substance abuse, coma history, pregnancy and breastfeeding women were excluded from this study

Design outcomes

Primary

MeasureTime frame
magnetic resonance imaging;DNA methylation;

Secondary

MeasureTime frame
cognitive function;

Countries

China

Contacts

Public ContactXiaogang Chen

The Second Xiangya Hospital of Central South University

chenxiaogang@csu.edu.cn+86 13607439166

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026