helicopter pylori and duodenal ulcer
Conditions
Interventions
1:rabeprazole 10 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and clarithromycin 500 mg b.i.d.
2:rabeprazole 10 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and tetracycline 750 mg b.i.d.
3:rabeprazole 20 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and clarithromycin 500 mg b.i.d.
4:rabeprazole 20 mg and bismuth 220 mg b.i.d., plus amoxicillin 1000 mg and tetracycline 750 mg b.i.d
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Consecutive H. pylori-infected patients with duodenal ulcers were prospectively recruited for this study. H. pylori infections were diagnosed by the 13C-urea breath test.
Exclusion criteria
Exclusion criteria: Exclusion criteria included the use of antibiotics and bismuth in the preceding 4 weeks or H2 receptor agonists and PPIs in the preceding 2 weeks, pregnancy or lactation at the time of the study, presence of clinically significant associated conditions (hepatic, cardiorespiratory or renal diseases; neoplastic diseases; or coagulopathy), allergy to any of the medications in the regimens (especially penicillin allergy), and previous gastric surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H. pylori eradication; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse event;H.pylori resistance rate; | — |
Countries
China
Contacts
Public ContactLu Nonghua
The First Affiliated Hospital of Nanchang University
Outcome results
None listed