Total knee arthroplasty?vertebral osteoporosis fractures
Conditions
Interventions
experimental group:Mineralized collagen bone cement
control group:Traditional bone cement
control group :Traditional bone cement
experimental group :Mineralized collagen bone cement
Sponsors
Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 100 Years
Inclusion criteria
Inclusion criteria: Evaluation of preclinical effect of mineralized collagen modified PMMA bone cement: 1. the mineralized collagen modified PMMA bone cement in the treatment of total knee arthroplasty (1) The in-patient male or female over 50 years of age; (2) The subjects was diagnosed with Osteoarthritis; (3) The subject requires unilateral or bilateral total knee arthroplasty (TKA); 2. Curative effect of mineralized collagen modified PMMA bone cement in vertebroplasty: (1) patients with the allergic history of the mineralized collagen modified PMMA bone cement active component or any component of the excipient; (2) The patients with local infection or potential infection; (3) The patients with the damage of the posterior wall of the vertebral body before the operation, which may lead to the leakage of the bone cement; In Vitro Biomechanical Study of Mineralized Collagen Modified PMMA Cements for Total Hip Replacement the femur specimen dealing with anticorrosion for one year.
Exclusion criteria
Exclusion criteria: Evaluation of preclinical effect of mineralized collagen modified PMMA bone cement: 1. the mineralized collagen modified PMMA bone cement in the treatment of total knee arthroplasty: (1) patients with the allergic history of the mineralized collagen modified PMMA bone cement active component or any component of the excipient; (2) The patients with local infection or potential infection. (3) The patient who have a knee disease which caused by Rheumatoid, ankylosing spondylitis and other autoimmune diseases; (4) Severe flexion deformity, varus valgus deformity need to use special prosthesis patients. 2. Curative effect of mineralized collagen modified PMMA bone cement in vertebroplasty (1) patients with the allergic history of the mineralized collagen modified PMMA bone cement active component or any component of the excipient; (2) The patients with local infection or potential infection; (3) The patients with the damage of the posterior wall of the vertebral body before the operation, which may lead to the leakage of the bone cement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HSS;visual analogue scale, VAS;Imaging evaluation;Evaluation of lower limb force line;Progress in thickness and luminance of bone cement;Safety index;visual analogue scale;The time to push the bone cement during the operation:The amount of bone cement injection during operation;Imaging evaluation;Leakage of bone cement;Re fracture rate of adjacent vertebral body;Safety index; | — |
Contacts
Public ContactXisheng Weng
Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences
Outcome results
None listed