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Effect of letrozole on endometrial preparation in frozen-thawed embryo transfer cycles

Effect of letrozole on endometrial preparation in frozen-thawed embryo transfer cycles: a prospective randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800014746
Enrollment
Unknown
Registered
2018-02-02
Start date
2018-04-01
Completion date
Unknown
Last updated
2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Controlled group:Follow the standard frozen-thawed embryo transfer cycle protocol
Experimental group:letrozole 2.5mg/d for 5 days since day 5 of menstrual cycle

Sponsors

The first affiliated hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Menstrual duration =35 days in normal times; 2. Patients diagnosed as PCOS; 3. Not older than 38.

Exclusion criteria

Exclusion criteria: 1. PGD cycles; 2. Existence of evidence of endometrial injury or abnormality; 3. Ultrasonographic evidence of a uterine abnormality (submucous myoma or adenomyoma); 4. Severe systemic diseases such as severe impairment of liver and kidney function; 5. Allergic to letrozole or hCG; 6. oral contraceptive pill usage within 3 months; 7. diagnosis of recurrent spontaneous abortion or pregnancy loss; 8. diagnosis of recurrent implantation failure

Design outcomes

Secondary

MeasureTime frame
clinical pregnancy rate;maternal complication rate;neonatal outcome;endometrium thickness;—

Primary

MeasureTime frame
live birth rate;—

Countries

China

Contacts

Public ContactQingyun Mai

The Reproductive Medicine Centre of the First Affiliated Hospital of Sun Yat-sen University

maiqingyun@aliyun.com+86 13724013011

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026