Autism spectrum disorders(ASD)
Conditions
Interventions
Oral capsule group:FMT
Enema group:FMT
Sponsors
Department of Gastroenterology, Institute of Surgery Research, Daping hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) Children aged from 3 to 18 years old; (2) Definitive diagnosis of autism; (3) The custodian of children can fully understand and accept the informed consent of the study and voluntarily participate in; (4) To be able to undergo follow-up examination; (5) Accompanying with symptoms of gastrointestinal tract (such as constipation, diarrhea, etc.); (6) No probiotics have been taken in the last month.
Exclusion criteria
Exclusion criteria: (1) The administration of probiotics and antibiotics; (2) Antibiotics were used in last 7 days before entry of the study; (3) Fever; (4) Relying on tube feeding; (5) Accompanying with gastrointestinal disease (such as life - threatening intestinal obstruction, intestinal perforation, intestinal bleeding, ulcerative colitis, Crohn disease, celiac disease, or eosinophilia esophagitis) requiring immediate treatment; (6) Combined diagnosis of severe malnutrition or excessive weight loss or severe immunodeficiency disease; (7) History of severe allergies; (8) Monogenic disease; (9) Accompanying with mental disorder or depression; (10) patients who were unable to cooperate to complete the study; (11) the researchers think that the paitent is not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal Permeability Analysis;Methane hydrogen exhalation test;16S ribosomal RNA approach for feces; | — |
Countries
China
Contacts
Public ContactLi Ning
Department of Gastroenterology, Institute of Surgery Research, Daping hospital, Third Military Medical University
Outcome results
None listed