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Involved-Field Irradiation Radiotherapy Combined with Chemotherapy vs Radiotherapy Alone for Elderly Patients With Esophageal Squamous Cell Carcinoma: A prospective, Open, Randomized Controlled of Clinical Outcomes and Toxicities

Involved-Field Irradiation Radiotherapy Combined with Chemotherapy vs Radiotherapy Alone for Elderly Patients With Esophageal Squamous Cell Carcinoma: A prospective, Open, Randomized Controlled of Clinical Outcomes and Toxicities

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800014739
Enrollment
Unknown
Registered
2018-01-31
Start date
2018-02-22
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

A:Radiotherapy combined with intravenous chemotherapy
B:Radiotherapy combined with oral chemotherapy
C:Only radiotherapy

Sponsors

Chinese PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
70 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged =70 years; 2. Clinical stages (cT2-3N0-2M0); 3. Pathological examination of esophageal squamous cell carcinoma; 4. For the first treatment, the operation could not be or refused to be excised; 5. ECOG score=2No contraindication of chemoradiotherapy; 6. Ability to understand the content of informed consent in radiotherapy and chemotherapy; 7. No accompanying history of other malignant tumors; 8. Complete case data.

Exclusion criteria

Exclusion criteria: 1. Non squamous cell carcinoma confirmed by pathology; 2. The results of examination and examination suggest the risk of perforation of the esophagus and the bleeding of the digestive tract; 3. Early I stage esophagus; 4. Distant metastasis; 5. Had received surgery, radiotherapy, chemotherapy, or associated with the history of other malignant tumors; 6. Contraindication with radiotherapy and chemotherapy; 7. Radiotherapy for conventional and three-dimensional conformal radiotherapy; 8. Chemotherapy needs more than 4 cycles.

Design outcomes

Primary

MeasureTime frame
PFS;

Secondary

MeasureTime frame
OS;side effects;pCR;

Countries

China

Contacts

Public ContactYan Maohui

General Hospital of PLA medical

yanmaohui1984@sina.com+86 18301071600

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026