Acute respiratory distress syndrome
Conditions
Interventions
control group:conventional therapy
Thymosin group:Thymosin 20mg intramuscular injection 1 times a day for 7 days
GM-CSF group:rhGM-CSF 250ug/m2 intravenous injection 1 times a day for 7 days
Sponsors
Xingtai People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: In accordance with the 2012 ARDS Berlin definition. And at the same time in line with the following conditions: 1. aged 18-70 years; 2. The primary disease of ARDS is a non pulmonary sepsis, which is in line with the definition of sepsis in 2016; 3. The patient or family members agree to join the clinical study.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Patients with malignant tumor, immunodeficiency and autoimmune disease; 3. The white blood cell count is more than 40 x 10^9/L or the oxygenation index is less than 80; 4. the patient or family members need to withdraw from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index;HLA-DR expression rate of CD14 positive mononuclear cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| concentration of HMGB-1, TNF-a, PCT and GM-CSF in Plasma .;Concentration of HMGB-1, TNF-a and GM-CSF in bronchoalveolar lavage fluid;Apche II score, SOFA score, and lung injury score;Duration of ventilator use, incidence of ventilator-associated pneumonia, death rate of 28 days; | — |
Countries
China
Contacts
Public ContactSun Jie
Department of ICU, Xingtai People's Hospital, Xingtai People's Hospital of Hebei
Outcome results
None listed