idiopathic focal segmental glomerulosclerosis
Conditions
Interventions
tacrolimus group:nothing
prednisone group:nothing
Sponsors
the First Affiliated Hospital of Third Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All patients were diagnosed with idiopathic focal segmental glomerulosclerosis by clinical and renal biopsy before treatment; 2. proteinuria is greater than 1g/24h; 3. Immunosuppressants were not used within 1 month before starting treatment; 4. All patients were given Angiotensin converting enzyme inhibitors or Angiotensin II receptor 1 blockers; 5. Aged between 12-54 years and sex is not limited.
Exclusion criteria
Exclusion criteria: 1) Hepatitis B, Henoch-Schonlein purpura, systemic lupus erythematosus secondary focal segmental gl omerulosclerosis; 2) Family history of kidney disease and other hereditary nephropathy; 3) Immunosuppressants such as azathioprine, mycophenolate mofetil, cyclosporine A, and leflunomide were taken within 1 month or at the beginning of the study; 4) Contraindications to tacrolimus or high-dose hormones (hepatitis virus carriers, chronic viral hepatitis, any active or serious infection); 5) Medication is not standardized or the treatment time is less than 6 months; 6) Tumor or other serious cases of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteinuria of 24 hour; | — |
Secondary
| Measure | Time frame |
|---|---|
| concentration of tacrolimus;remission rate;Recurrence rate; | — |
Countries
China
Contacts
Public ContactHongwen Zhao
Outcome results
None listed