Cerebrovascular disease
Conditions
Interventions
test group:Low-dose alteplase and tirofiban
Control group:standard single-dose rt-PA treatment
Sponsors
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. age = 18 years; 2. onset 4.5h; 3. diagnosis of ischemic stroke, a clear neurological deficit; 4. no prior atrial fibrillation, severe heart disease patients; 5. admission NIHSS score <15 points; 6. brain CT has ruled out intracranial hemorrhage; 7. family members signed informed consent.
Exclusion criteria
Exclusion criteria: 1. More than 4.5h onset of patients; 2. Previous history of atrial fibrillation or severe heart disease; 3. Previous history of intracranial hemorrhage; 4. symptoms suggest subarachnoid hemorrhage; 5. existence of intracranial tumors, arteriovenous malformations or aneurysms; 6. nearly 3 months have a history of severe head injury or cerebral infarction, but does not include the old small lacunar infarction Symptoms and signs; 7. nearly a week difficult to oppress the site of hemostasis arterial puncture; 8. severe liver and kidney dysfunction or severe diabetes; 9. accompanied by active bleeding; 10. blood glucose 185 mmHg or diastolic blood pressure> 110 mmHg; 11. Platelet count below normal; oral anticoagulant with INR> 1.7.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score;mRS score three months after thrombolysis;symptomatic hemorrhage;Non-symptomatic hemorrhage;Blood coagulation index;Blood cell test; | — |
Countries
China
Contacts
Public ContactLiang Zhigang
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University
Outcome results
None listed