blood disease after single unit umbilical cord blood transplantation or HLA-matched related allogeneic hematopoietic stem cell transplantation
Conditions
Interventions
group treated with UCBT:Patients are treated with single unit umbilical cord blood transplantation
group treated with HLA-matched related HSCT:Patients are treated with HLA-matched related hematopoetic stem cell transplantation
Sponsors
Anhui Provincial Hospital
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with hemaotogical diseases needed allo-HSCT according to Expert consensus on the treatment of hematological diseases by allogeneic hematopoietic stem cell transplantation in China; 2. Patients aged = 14 years, any gender, any race; 3. No severe organ failure and active infection; 4. Patients and their families voluntarily carry out UCBT or HLA-matched related HSCT and sign informed consent; 5. Patients and their families voluntarily participate in this research and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious viscera dysfunction or disease, such as serious diseases and function disorder in heart, liver, kidney and pancreas; 2. Patients aged less than 14 years; 3. Patients with drug dependence, uncontrolled mental disease or cognitive impairment; 4. Participate in other similar clinical researches in 3 months; 5. Researchers think that the patient doesn't fit into the group (e.g., patients are expected to be discontinue because of funding problems).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 180d FACT-BMT total score; | — |
Secondary
| Measure | Time frame |
|---|---|
| FACT-BMT Physical Well-Being (PWB) Score;FACT-BMT Social/Family Well-Being (SWB) Score;FACT-BMT Emotional Well-Being (EWB) Score;FACT-BMT Functional Well-Being (FWB) Score;FACT-BMT Trial Outcome Index (TOI);FACT-G total score;SF-36 Physical Functionin (PF) score;SF-36 Role-Physical (RP) score;SF-36 Bodily Pain (BP) score;SF-36 General Health (GH) score;SF-36 Vitality (VT) score;SF-36 Social Functioning (SF) score;SF-36 Role-Emotional (RE) score;SF-36 Mental Health (MH) score;Cumulative incidence of acute GVHD;Cumulative incidence of chronic GVHD;180d transplant related mortality (TRM);relapse rate;Cumulative rate of neutrophil engraftment;Cumulative rate of platelet engraftment;neutrophil engraftment time;platelet engraftment time; | — |
Countries
China
Contacts
Public ContactZimin Sun
Department of Hematology, Anhui Provincial Hospital
Outcome results
None listed