Depressive disorders
Conditions
Interventions
Children and adolescents treatment group:Fluoxetine+inosine
Children and adolescents control group:Fluoxetine+inosine placebo
Adult treatment group:Fluoxetine+inosine
Adult control group:Fluoxetine+inosine placebo
Sponsors
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
4 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with depressive disorders by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-5); (2) Children and adolescents aged from 4 to 17 and adults aged from 18 to 65 years; (3) Children's Depression Rating Scale - Revised (CDRS-R) total scores=40 in children and adolescents and Hamilton Depression Scale - 17 items (HAMD-17) in adults; (4) Providing written informed consent informed consent (children and adolescents need signature of guardian).
Exclusion criteria
Exclusion criteria: (1) Taking drugs that are interfering or contraindicated with the test drugs, taking antidepressants within a month, having serious side effects of test drugs, or being allergic to test drugs; (2) Patients diagnosed with organic mental disorders, mental disorders caused by psychoactive substances, refractory depression (respond poorly to appropriate courses of at least two antidepressants), schizophrenia, bipolar disorder, somatoform disorders; (3) Patients diagnosed with severe physical diseases or in other life-threatening conditions; (4) Having a history of substance abuse such as drug, alcohol or having a risk of suicide; (5) Patients with mental retardation or severe cognitive impairment; (6) Pregnant or nursing women; (7) Participating in the clinical research currently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety symptoms;Suicide severity;Life quality evaluation;Clinical global impression;Safety evaluation; | — |
Countries
China
Contacts
Public ContactPeng Xie
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed