cerebral infarction
Conditions
Interventions
Case series:Saponins of Tribulus terrestris in the treatment of cerebral infarction
Sponsors
Dongzhimen Hospital of Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) conforming to the criteria for the diagnosis of cerebral infarction in western medicine; (2) conforming to the diagnostic criteria for the recovery period of meridians and collaterals in Chinese medicine; (3) the syndrome of syndrome differentiation of traditional Chinese medicine is wind phlegm stasis syndrome; (4) imaging (CT or MRI) confirmed that OCSP was clinically classified as complete anterior circulation infarction (TACI) or partial anterior circulation infarction (PACI) or posterior circulation infarction. (5) NIHSS score greater than 5 and less than or equal to 22 points; (6) patients with recurrent or recurrent cerebral infarction were completely or completely recovered before the onset of the disease (mRS score was 0~1 points). (7) the course of the disease was 2 weeks to 3 months after the onset of the disease; (8) aged 35~80 years male and female; (9) voluntary subjects and the signing of the informed consent.
Exclusion criteria
Exclusion criteria: (1) progressive stroke, transient ischemic attack, cerebral hemorrhage after cerebral infarction and patients with cerebral arteritis; (2) patients with brain tumor, brain injury, brain parasitopathy and other diseases that affect the evaluation of drug efficacy; (3) combined with other diseases that affect limb movement function, limb movement dysfunction caused by claudication, osteoarthritis, rheumatoid arthritis and gouty arthritis may affect nerve function examiners before treatment; (4) patients with severe cardiac insufficiency, renal insufficiency, severe mental illness, depression after stroke, and dementia; (5) ALT, AST > upper limit of normal value of 1.5 times or Scr and BUN > upper limit of normal value; (6) patients with diabetic nephropathy; (7) suffering from severe hypertension, taking antihypertensive drugs after the systolic blood pressure, diastolic blood pressure, 90mmHg is more than 160mmHg, or hypotension (resting sitting blood pressure less than 90 mmHg) systolic blood pressure, diastolic blood pressure less than 50mmHg) patients; (8) patients who have undergone intravascular therapy, or in the screening period, are estimated to be required for intravascular treatment; (9) women in pregnancy or lactation; (10) those who were allergic to the known ingredients in this trial; (11) active ulcers and patients with bleeding tendency; (12) other clinical researchers were attended 3 months before the trial; (13) the researchers believe that others should not be involved in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Barthel Index;NIH Stroke Scale, NIHSS;TCM syndrome score;Single symptom of traditional Chinese Medicine;Recurrence rate and death rate (180th days after the onset of the disease); | — |
Countries
China
Contacts
Public ContactZHANG GEN MING
Beijing University of Chinese Medicine Dongzhimen Hospital
Outcome results
None listed