extremities fracture
Conditions
Interventions
A group:The patients were treated on their own by taking acetaminophen tablets (325mg acetaminophen + 5mg oxycodone), and routinely giving pain management and education on the dosage
B group:The patients were treated on their own by taking paracetamol tablets (500mg acetaminophen), and routinely giving pain management and education on the dosage
Sponsors
Shanghai Jiaotong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) complaint of acute pain of less than seven days duration; 2) location of pain in one or more extremities defined as distal to and including the shoulder joint in the upper extremities and distal to and including the hip joint in the lower extremities; 3) radiologic evaluation is planned; 4) limb fractures, conservative treatment; 5) aged 18-100 years of age, gender is not limited; 6) informed consent and signed informed consent.
Exclusion criteria
Exclusion criteria: 1) accompanied by other non-limb fractures; 2) accompanied by blood vessels, nerves, tendon injury; 3) open fractures; 4) chronic condition requiring frequent pain management such as sickle cell disease, fibromyalgia, or any neuropathy 5) past use of methadone; 6) history of an adverse reaction to any of the study medications; 7) history of peptic ulcer; 8) report of any prior use of recreational narcotics; 9) medical condition that might affect metabolism of opioid analgesics, acetaminophen, or ibuprofen such as hepatitis, renal insufficiency or failure, hypo- or hyperthyroidism, Addisons or Cushings disease; 10) taking any medicine that might interact with one of the study medications, such as antidepressant SSRIs or Tricyclics, antipsychotics, anti-malaria medications quinidine or halofantrine, Amiodarone or Dronedarone, diphenhydramine, celecoxib, ranitidine, cimetidine, ritanovir, terbinafine, or St Johns Wort; 11) accompanied by mental illness history, dementia, etc. can not be normal, accurate communication and answer questions; 12) physically handicapped; incapacitated; 13) do not want or can not cooperate with the data collector; 14) maternal and other incompatible persons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety and depression scale;EQ-5d Quality of Life Scale;Satisfaction with analgesia (0-10 points);Changes in sleep time; | — |
Countries
China
Contacts
Public ContactXianyou Zheng
Shanghai Jiaotong University Affiliated Sixth People's Hospital
Outcome results
None listed