Diabetes Mellitus
Conditions
Interventions
trial group:fecal microbiota transplantation
control group:conventional therapy
Sponsors
First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged from 18 to 75 years. 2.Diagnosis of type 1 diabetes whose glycemia is poorly controlled with insulin treatment for more than 6 months.Manifested as follows:FPG fluctuation >5.55mmol/L;2h-PG fluctuation = 11.1mmol/L;urinary ketone body positive repeatedly;hypoglycaemic events occur unpredictably.3.Diagnosis of type 2 diabetes whose glycemia is poorly controlled with insulin dose over 0.8U/kg.d and (or)combining oral antidiabetic drugs more than 6 months. 4.Patients volunteered to participate in and sign the consent form.
Exclusion criteria
Exclusion criteria: 1.severe diabetic complications,such as severe retinopathy,ulcer,etc;2.had gastric or intestinal surgery which caused changes in the anatomy of the gastrointestinal tract;3.had other autoimmune diseases,such as inflammatory bowel disease,systemic lupus erythematosus,etc;4.patients with pregnancy or having a fertility plan;5.patients with drugs or other substance abusers;6.Alcoholics:Subjects consuming> 2 servings of alcoholic beverages or> 14 servings per day (one Alcoholic beverages are defined as 150ml of wine, or 350ml of beer, or 50ml The standard degree of 80% (40 degrees) of spirits);7.Have a history of severe allergy; 8.patients with severe heart,liver,renal insufficiency,severe cerebrovascular and lung disease;9.reduce weight by any drugs or surgery;10.participants who taking antibiotics within 3 months or probiotics within 4 weeks;11.patients can not cooperate with clinical researchers for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose level;HbA1C;Serum c-peptide levels;Serum insulin level;Gut Microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP;IL-6; | — |
Countries
China
Contacts
Public ContactJixiong Xu
First Affiliated Hospital of Nanchang University?
Outcome results
None listed