AECOPD
Conditions
Interventions
HFNC group:nasal high flow oxygen therapy
NPPV group:noninvasive positive pressure ventilation, NPPV
Sponsors
People's Hospital of North Jiangsu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. AECOPD was diagnosed; 2. Blood gas analysis pH 7.25-7.35, PaCO2>50 mmHg.
Exclusion criteria
Exclusion criteria: 1. Less than 18 years of age; 2. No informed consent was obtained; 3. Severe respiratory failure requiring tracheal intubation: RR > 40 times / min, severe hypoxia high concentration oxygen P/F was lower than 150, severe respiratory acidosis PH < 7.25, disturbance of consciousness GCS < 8; 4. NPPV contraindications: orofacial trauma, sputum expectoration ability, hemodynamic instability etc.; 5. Patients with short term prognosis,those with a high risk of death within 7 days,undergoing palliative care; 6. Other organs failure; 7. Tracheotomy has been performed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| arterial blood gas;respiratory rate;heart rate;blood pressure;Daily treatment time and parameter setting of NPPV and HFNC;Change and time of respiratory support;Whether invasive ventilation (endotracheal intubation) and time;Dyspnea score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comfort score;Facial skin breakage;Number of daily nursing interventions (due to respiratory support);Respiratory and extrapulmonary complications;ICU length of stay and total length of stay;Discharge (death, healed / improved); | — |
Countries
China
Contacts
Public ContactDingyu Tan
People's Hospital of North Jiangsu
Outcome results
None listed