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Study on the mechanism of traditional Chinese medicine in the treatment of Myelodysplastic Syndrome

Research on HDAC1 gene demethylation mediated regulating HIF-1/EPO signal pathway mechanism for Qinghuang powder combined with tonifying kidney and strengthening spleen prescription in treating Myelodysplastic Syndrome

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800014524
Enrollment
Unknown
Registered
2018-01-18
Start date
2016-07-01
Completion date
Unknown
Last updated
2018-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myelodysplastic Syndrome

Interventions

Myelodysplastic Syndrome:Qinghuang powder combined with tonifying kidney and strengthening spleen prescription

Sponsors

Beijing Chinese Medicine Hospital affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who accord with MDS diagnostic criteria; 2. Patients who volunteer and sign informed consent; 3. Aged 18-75 years old; 4. Patients without serious complications in liver and kidney; 5. Patients who is not participating in other clinical studies.

Exclusion criteria

Exclusion criteria: 1. Patients with serious complications in Heart liver and kidney; 2. Patients with mental illness can not be matched with the treatment; 3. Pregnant women and Lactating women and patients with mental illness; 4. Patients who happen serious adverse reactions during the medication and be allergic to the drug; 5. Patients who is participating in other clinical studies.

Design outcomes

Primary

MeasureTime frame
HDAC1 gene;

Secondary

MeasureTime frame
HIF-1a mRNA;HIF-1a protein levels;EPO;

Countries

China

Contacts

Public ContactGao Fei

Beijing Chinese Medicine Hospital affiliated to Capital Medical University

gaofeivera@163.com+86 13811915291

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026