Obstructive sleep apnea and hypopnea syndrome
Conditions
Interventions
Surgery:tonsillectomy and adenoidectomy
Observation:Obeserve
Sponsors
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 40,000 students from 47 primary school in Xuhui District, Shanghai, who participate in annual physical examination every year; 2. Children's parents give informed consent; 3. Children's parents able to answer the questionnaires.
Exclusion criteria
Exclusion criteria: 1. For epidemiological study: no exclusion criteria; 2. For control study: (1) Severe systemic diseases (e.g., cardiac, hepatic, and renal failure) (2) Sleep disorders other than OSA (narcolepsy, insomnia, chronic sleep deprivation, rapid eye movement [REM] behavior disorder and restless legs syndrome, central sleep apnea or obesity hypoventilation syndrome)Severe systemic diseases (e.g., cardiac, hepatic, and renal failure); (3) Infectious, tumor or trauma history; (4) Prior therapy for OSA (i.e., CPAP, upper airway surgery, oral appliance).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gozal behavioral questionnaire;Strengths and Difficulties Questionnaire;NEPSY cognitive test;DAS cognitive test; | — |
Secondary
| Measure | Time frame |
|---|---|
| OSA symptom questionnaire;OSA-18 questionnaire;Apnea hypopnea syndrome;oxygen desaturation index;lowest oxygen saturation;average oxygen saturation;reading ability;school performance;CRP;IL-6;Genome;proteome;metabonomics;metagenome;functional MRI; | — |
Countries
China
Contacts
Public ContactShankai Yin
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed