Pancreatic tumor
Conditions
Interventions
Group A(Acute hypervolemic fluid infusion group):During the induction period (30min before and after induction),infusion is 25ml/kg, and continuous infusion of 8ml/kg/h during the operation (colloid a
Group T(Traditional group):During the induction period, the infusion is 5ml/kg, physiological demand and preoperative loss are supplemented by 4-2-1, intraoperative blood loss is infused by colloid a
Sponsors
Ruijin hospital, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients who aged 18-75y, ASA I to III, BMI18-30kg/m2, Hb>80g/L and HCT>30%, selected for the pancreatic operation , including D- segment pancreatectomy, pancreatectomy, pancreatoduodenectomy, pancreatoduodenectomy, pancreatoduodenectomy, pancreatoduodenectomy etc.
Exclusion criteria
Exclusion criteria: 1. Any cerebrovascular accident occurred in 3 months, such as stroke, transient ischemic attack (TIA) and so on; 2. Serious abnormal liver and kidney function; 3. There are severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macroangiopathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot); 4. Unstable angina, myocardial infarction or patients with severe arrhythmia in 3 months; 5. In severe sedation blood pressure = 160/100mmHg(WHO-ISH = 160/100 mm Hg blood pressure hypertension guidelines 2/3 hypertension); 6. Pulmonary ventilation function or diffuse function in severe disorder; 7. Severe pancreatitis; 8. There is a contraindication or anaphylaxis of narcotic drugs; 9. The accuracy of the monitoring data (aortic balloon counterpulsation, pacemaker, peripheral vascular disease); 10. Coagulation disorders and serious electrolyte disorders; 11. Patients who participated in other studies within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lactate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cycle stability :the value of each time point SBP, DBP, MAP, HR, SVV, CI, CVP, II/V1/aVL- ST. 2. Liver and kidney function before surgery within three days and the day after operation: ALT, AST, total bilirubin, creatinine, urea, Hb/Hct. 3. Postoperative complications :conjunctival edema, subcutaneous emphysema,; | — |
Countries
China
Contacts
Public ContactYan Luo
Department of Anesthesiology, Ruijin hospital, Ruijin hospital, Shanghai
Outcome results
None listed